GREACE-assisted adaptive laboratory evolution in endpoint fermentation broth enhances lysine production by Escherichia coli

GREACE-assisted adaptive laboratory evolution in endpoint fermentation broth enhances lysine production by Escherichia coli

Abstract Background Late-stage fermentation broth contains high concentrations of target chemicals. Additionally, it contains various cellular metabolites which have leaked from lysed cells, which would exert multifactorial stress to industrial hyperproducers and perturb both cellular metabolism and...

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Bibliographic Details
Main Authors: Xiaowei Wang, Qinggang Li, Cunmin Sun, Zhen Cai, Xiaomei Zheng, Xuan Guo, Xiaomeng Ni, Wenjuan Zhou, Yanmei Guo, Ping Zheng, Ning Chen, Jibin Sun, Yin Li, Yanhe Ma
Format: Article
Language:English
Published: BMC 2019-06-01
Series:Microbial Cell Factories
Subjects:
Lysine production
Escherichia coli
Adaptive laboratory evolution
GREACE
Fermentation broth
Online Access:http://link.springer.com/article/10.1186/s12934-019-1153-6

Internet

http://link.springer.com/article/10.1186/s12934-019-1153-6

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