Design, Synthesis and Cytotoxicity Screening of New Thiazole Derivatives as Potential Anticancer Agents through VEGFR-2 Inhibition

Design, Synthesis and Cytotoxicity Screening of New Thiazole Derivatives as Potential Anticancer Agents through VEGFR-2 Inhibition

<i>Z</i>-configurated isomers are kinetically preferred molecules. Compounds with <i>Z</i>-configuration are contained in many natural products, biologically active compounds and as synthons for organic synthesis. Two series of new thiazole-based analogs were synthesized from...

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Bibliographic Details
Main Authors: Tarfah Al-Warhi, Matokah Abualnaja, Ola A. Abu Ali, Najiah M. Alyamani, Fahmy G. Elsaid, Ali A. Shati, Sarah Albogami, Eman Fayad, Ali H. Abu Almaaty, Khaled O. Mohamed, Wael M. Alamoudi, Islam Zaki
Format: Article
Language:English
Published: MDPI AG 2022-09-01
Series:Symmetry
Subjects:
<i>Z</i>-configurated isomers
thiazole
hydrazinecarbothioamide
phenacylbromide
cytotoxicity
VEGFR-2
Online Access:https://www.mdpi.com/2073-8994/14/9/1814

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https://www.mdpi.com/2073-8994/14/9/1814

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