Spatial patterns of CTCF sites define the anatomy of TADs and their boundaries

Spatial patterns of CTCF sites define the anatomy of TADs and their boundaries

Abstract Background Topologically associating domains (TADs) are genomic regions of self-interaction. Additionally, it is known that TAD boundaries are enriched in CTCF binding sites. In turn, CTCF sites are known to be asymmetric, whereby the convergent configuration of a pair of CTCF sites leads t...

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Bibliographic Details
Main Authors: Luca Nanni, Stefano Ceri, Colin Logie
Format: Article
Language:English
Published: BMC 2020-08-01
Series:Genome Biology
Subjects:
Chromatin architecture
TADs
TAD boundary conservation
CTCF binding site clusters
CTCF orientation patterns
Loop extrusion
Online Access:http://link.springer.com/article/10.1186/s13059-020-02108-x

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http://link.springer.com/article/10.1186/s13059-020-02108-x

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