Dysregulation of TNF-α and IFN-γ expression is a common host immune response in a chronically infected mouse model of melioidosis when comparing multiple human strains of Burkholderia pseudomallei

Dysregulation of TNF-α and IFN-γ expression is a common host immune response in a chronically infected mouse model of melioidosis when comparing multiple human strains of Burkholderia pseudomallei

Abstract Background Melioidosis is endemic in Southeast Asia and Northern Australia and is caused by the Gram-negative, facultative intracellular pathogen Burkholderia pseudomallei. Diagnosis of melioidosis is often difficult because of the protean clinical presentation of the disease, and it may mi...

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Bibliographic Details
Main Authors: Kei Amemiya, Jennifer L. Dankmeyer, Jeremy J. Bearss, Xiankun Zeng, Spencer W. Stonier, Carl Soffler, Christopher K. Cote, Susan L. Welkos, David P. Fetterer, Taylor B. Chance, Sylvia R. Trevino, Patricia L. Worsham, David M. Waag
Format: Article
Language:English
Published: BMC 2020-02-01
Series:BMC Immunology
Subjects:
Burkholderia pseudomallei
Chronic infection
BALB/c mice
Pyogranulomatous lesion
Inflammatory cytokines
Intracellular TNFα and IFNγ
Online Access:https://doi.org/10.1186/s12865-020-0333-9

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https://doi.org/10.1186/s12865-020-0333-9

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