Two novel UPLC methods utilizing two different analytical columns and different detection approaches for the simultaneous analysis of velpatasvir and sofosbuvir: application to their co-formulated tablet

Two novel UPLC methods utilizing two different analytical columns and different detection approaches for the simultaneous analysis of velpatasvir and sofosbuvir: application to their co-formulated tablet

Abstract In the present study two different RSLC columns, Acclaim RSLC 120 C18, 5.0 µm, 4.6 × 150 mm (column A) and Acclaim RSLC 120 C18, 2.2 µm, 2.1 × 100 mm (Column B) were utilized for the analysis of velpatasvir (VPS) in presence of sofosbuvir (SFV), where due to the encountered fluorescent prop...

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Bibliographic Details
Main Authors: Moustapha Eid Moustapha, Rania Mohamed El-Gamal, Fathalla Fathalla Belal
Format: Article
Language:English
Published: BMC 2019-09-01
Series:BMC Chemistry
Subjects:
Velpatasvir
Sofosbuvir
UPLC
Fluorescent detection
UV-spectrophotometric detection
Online Access:http://link.springer.com/article/10.1186/s13065-019-0635-2

Internet

http://link.springer.com/article/10.1186/s13065-019-0635-2

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