Live attenuated TB vaccines representing the three modern Mycobacterium tuberculosis lineages reveal that the Euro–American genetic background confers optimal vaccine potential

Live attenuated TB vaccines representing the three modern Mycobacterium tuberculosis lineages reveal that the Euro–American genetic background confers optimal vaccine potential

Background: Human tuberculosis (TB) is caused by a plethora of Mycobacterium tuberculosis complex (MTBC) strains belonging to seven phylogenetic branches. Lineages 2, 3 and 4 are considered “modern” branches of the MTBC responsible for the majority of worldwide TB. Since the current BCG vaccine conf...

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Bibliographic Details
Main Authors: Irene Pérez, Santiago Uranga, Fadel Sayes, Wafa Frigui, Sofía Samper, Ainhoa Arbués, Nacho Aguiló, Roland Brosch, Carlos Martín, Jesús Gonzalo-Asensio
Format: Article
Language:English
Published: Elsevier 2020-05-01
Series:EBioMedicine
Subjects:
Tuberculosis
Virulence
Live vaccines
Epidemiology
Pathogen evolution
PDIM
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396420301365

Internet

http://www.sciencedirect.com/science/article/pii/S2352396420301365

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