SREBP1 regulates Lgals3 activation in response to cholesterol loading

SREBP1 regulates Lgals3 activation in response to cholesterol loading

Aberrant smooth muscle cell (SMC) plasticity is etiological to vascular diseases. Cholesterol induces SMC phenotypic transition featuring high LGALS3 (galectin-3) expression. This proatherogenic process is poorly understood for its molecular underpinnings, in particular, the mechanistic role of ster...

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Bibliographic Details
Main Authors: Jing Li, Hongtao Shen, Gary K. Owens, Lian-Wang Guo
Format: Article
Language:English
Published: Elsevier 2022-06-01
Series:Molecular Therapy: Nucleic Acids
Subjects:
vascular smooth muscle cell
cholesterol loading
phenotypic transition
SREBP1
LGALS3
feedforward circuit
Online Access:http://www.sciencedirect.com/science/article/pii/S216225312200141X

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http://www.sciencedirect.com/science/article/pii/S216225312200141X

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