Atazanavir/Ritonavir Increased Tizoxanide Exposure from Oral Nitazoxanide through Pharmacokinetic Interaction in Healthy Volunteers

Atazanavir/Ritonavir Increased Tizoxanide Exposure from Oral Nitazoxanide through Pharmacokinetic Interaction in Healthy Volunteers

Nitazoxanide use is limited by gastrointestinal side effects associated with increasing dose. In this drug repurposing study, we investigated the possibility of enhancing the exposure of its active metabolite, tizoxanide, through pharmacokinetic interaction with atazanavir/ritonavir. In this crossov...

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Bibliographic Details
Main Authors: Abdulafeez Akinloye, Timothy Oyedeji, Oluwasegun Eniayewu, Babatunde Adeagbo, Oluseye Bolaji, Steve Rannard, Andrew Owen, Adeniyi Olagunju
Format: Article
Language:English
Published: MDPI AG 2024-02-01
Series:Future Pharmacology
Subjects:
nitazoxanide
tizoxanide
atazanavir/ritonavir
drug–drug interaction
dried blood spot
Online Access:https://www.mdpi.com/2673-9879/4/1/11

Internet

https://www.mdpi.com/2673-9879/4/1/11

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