Unilateral intranigral administration of β-sitosterol β-D-glucoside triggers pathological α-synuclein spreading and bilateral nigrostriatal dopaminergic neurodegeneration in the rat

Unilateral intranigral administration of β-sitosterol β-D-glucoside triggers pathological α-synuclein spreading and bilateral nigrostriatal dopaminergic neurodegeneration in the rat

Abstract The spreading and accumulation of α-synuclein and dopaminergic neurodegeneration, two hallmarks of Parkinson’s disease (PD), have been faithfully reproduced in rodent brains by chronic, oral administration of β-sitosterol β-D-glucoside (BSSG). We investigated whether a single injection of B...

Full description

Bibliographic Details
Main Authors: Luis O. Soto-Rojas, Irma A. Martínez-Dávila, Claudia Luna-Herrera, María E. Gutierrez-Castillo, Francisco E. Lopez-Salas, Bismark Gatica-Garcia, Guadalupe Soto-Rodriguez, María Elena Bringas Tobon, Gonzalo Flores, America Padilla-Viveros, Cecilia Bañuelos, Víctor Manuel Blanco-Alvarez, José Dávila-Ayala, David Reyes-Corona, Linda Garcés-Ramírez, Oriana Hidalgo-Alegria, Fidel De La Cruz-lópez, Daniel Martinez-Fong
Format: Article
Language:English
Published: BMC 2020-04-01
Series:Acta Neuropathologica Communications
Subjects:
Lewy body-like synuclein aggregations
Parkinson’s disease
BSSG
Sensorimotor alterations
Bilateral affectation
Synuclein spreading
Online Access:http://link.springer.com/article/10.1186/s40478-020-00933-6

Internet

http://link.springer.com/article/10.1186/s40478-020-00933-6

Similar Items