Inhibitory and excitatory synaptic neuroadaptations in the diazepam tolerant brain

Inhibitory and excitatory synaptic neuroadaptations in the diazepam tolerant brain

Benzodiazepine (BZ) drugs treat seizures, anxiety, insomnia, and alcohol withdrawal by potentiating γ2 subunit containing GABA type A receptors (GABAARs). BZ clinical use is hampered by tolerance and withdrawal symptoms including heightened seizure susceptibility, panic, and sleep disturbances. Here...

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Bibliographic Details
Main Authors: Joshua M. Lorenz-Guertin, Nadya Povysheva, Caitlyn A. Chapman, Matthew L. MacDonald, Marco Fazzari, Aparna Nigam, Jessica L. Nuwer, Sabyasachi Das, Megan L. Brady, Katarina Vajn, Matthew J. Bambino, Susan T. Weintraub, Jon W. Johnson, Tija C. Jacob
Format: Article
Language:English
Published: Elsevier 2023-09-01
Series:Neurobiology of Disease
Subjects:
Benzodiazepine
GABAA receptor
NMDA receptor
Sedation
Tolerance
Proteomics
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996123002632

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http://www.sciencedirect.com/science/article/pii/S0969996123002632

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