Nucleotide Analogues Bearing a C2′ or C3′-Stereogenic All-Carbon Quaternary Center as SARS-CoV-2 RdRp Inhibitors

Nucleotide Analogues Bearing a C2′ or C3′-Stereogenic All-Carbon Quaternary Center as SARS-CoV-2 RdRp Inhibitors

The design of novel nucleoside triphosphate (NTP) analogues bearing an all-carbon quaternary center at C2′ or C3′ is described. The construction of this all-carbon stereogenic center involves the use of an intramoleculer photoredox-catalyzed reaction. The nucleoside analogues (NA) hydroxyl functiona...

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Bibliographic Details
Main Authors: Amarender Manchoju, Renaud Zelli, Gang Wang, Carla Eymard, Adrian Oo, Mona Nemer, Michel Prévost, Baek Kim, Yvan Guindon
Format: Article
Language:English
Published: MDPI AG 2022-01-01
Series:Molecules
Subjects:
SARS-CoV-2
COVID-19
RdRp
quaternary stereocenter
nucleoside analogues
epoxidation
Online Access:https://www.mdpi.com/1420-3049/27/2/564

Internet

https://www.mdpi.com/1420-3049/27/2/564

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