Towards a New Generation of Hormone Therapies: Design, Synthesis and Biological Evaluation of Novel 1,2,3-Triazoles as Estrogen-Positive Breast Cancer Therapeutics and Non-Steroidal Aromatase Inhibitors

Towards a New Generation of Hormone Therapies: Design, Synthesis and Biological Evaluation of Novel 1,2,3-Triazoles as Estrogen-Positive Breast Cancer Therapeutics and Non-Steroidal Aromatase Inhibitors

Aromatase inhibitors (AIs) show promising features as drugs to treat estrogen-responsive breast cancer as they block aromatase activity, the key enzyme in estrogen synthesis. The current AIs approved by the Food and Drug Administration for breast cancer treatment present severe adverse effects. For...

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Bibliographic Details
Main Authors: Huda R. M. Rashdan, Mohamad T. Abdelrahman, Anna Chiara De Luca, Maria Mangini
Format: Article
Language:English
Published: MDPI AG 2024-01-01
Series:Pharmaceuticals
Subjects:
1,2,3-triazoles
aromatase inhibitors
breast cancer
hormone therapy
gelatin degradation
RNA extraction and real-time qPCR
Online Access:https://www.mdpi.com/1424-8247/17/1/88

Internet

https://www.mdpi.com/1424-8247/17/1/88

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