Engineering Calreticulin-Targeting Monobodies to Detect Immunogenic Cell Death in Cancer Chemotherapy

Engineering Calreticulin-Targeting Monobodies to Detect Immunogenic Cell Death in Cancer Chemotherapy

Surface-exposed calreticulin (ecto-CRT) plays a crucial role in the phagocytic removal of apoptotic cells during immunotherapy. Ecto-CRT is an immunogenic signal induced in response to treatment with chemotherapeutic agents such as doxorubicin (DOX) and mitoxantrone (MTX), and two peptides (KLGFFKR...

Full description

Bibliographic Details
Main Authors: Ying Zhang, Ramar Thangam, Sung-Hwan You, Rukhsora D. Sultonova, Akhil Venu, Jung-Joon Min, Yeongjin Hong
Format: Article
Language:English
Published: MDPI AG 2021-06-01
Series:Cancers
Subjects:
monobody
calreticulin
immunogenic cell death (ICD)
optical bioluminescence imaging
early prediction of chemotherapeutic response
Online Access:https://www.mdpi.com/2072-6694/13/11/2801

Internet

https://www.mdpi.com/2072-6694/13/11/2801

Similar Items