Discovery and Biological Evaluation of a Series of Pyrrolo[2,3-b]pyrazines as Novel FGFR Inhibitors

Discovery and Biological Evaluation of a Series of Pyrrolo[2,3-b]pyrazines as Novel FGFR Inhibitors

Abnormality of fibroblast growth factor receptor (FGFR)-mediated signaling pathways were frequently found in various human malignancies, making FGFRs hot targets for cancer treatment. To address the consistent need for a new chemotype of FGFR inhibitors, here, we started with a hit structure identif...

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Bibliographic Details
Main Authors: Yan Zhang, Hongchun Liu, Zhen Zhang, Ruifeng Wang, Tongchao Liu, Chaoyun Wang, Yuchi Ma, Jing Ai, Dongmei Zhao, Jingkang Shen, Bing Xiong
Format: Article
Language:English
Published: MDPI AG 2017-04-01
Series:Molecules
Subjects:
FGFR1
inhibitor
kinase inhibitor
pyrazine
hinge binder
Online Access:http://www.mdpi.com/1420-3049/22/4/583

Internet

http://www.mdpi.com/1420-3049/22/4/583

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