New Hybrid Tetrahydropyrrolo[3,2,1-<i>ij</i>]quinolin-1-ylidene-2-thioxothiazolidin-4-ones as New Inhibitors of Factor Xa and Factor XIa: Design, Synthesis, and In Silico and Experimental Evaluation

New Hybrid Tetrahydropyrrolo[3,2,1-<i>ij</i>]quinolin-1-ylidene-2-thioxothiazolidin-4-ones as New Inhibitors of Factor Xa and Factor XIa: Design, Synthesis, and In Silico and Experimental Evaluation

Despite extensive research in the field of thrombotic diseases, the prevention of blood clots remains an important area of study. Therefore, the development of new anticoagulant drugs with better therapeutic profiles and fewer side effects to combat thrombus formation is still needed. Herein, we rep...

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Bibliographic Details
Main Authors: Nadezhda P. Novichikhina, Alexander S. Shestakov, Svetlana M. Medvedeva, Anna M. Lagutina, Mikhail Yu. Krysin, Nadezhda A. Podoplelova, Mikhail A. Panteleev, Ivan S. Ilin, Alexey V. Sulimov, Anna S. Tashchilova, Vladimir B. Sulimov, Athina Geronikaki, Khidmet S. Shikhaliev
Format: Article
Language:English
Published: MDPI AG 2023-05-01
Series:Molecules
Subjects:
5,6-dihydro-4<i>H</i>-pyrrolo[3,2,1-<i>ij</i>]quinoline-1,2-dione
rhodanines
anticoagulant activity
docking studies
Online Access:https://www.mdpi.com/1420-3049/28/9/3851

Internet

https://www.mdpi.com/1420-3049/28/9/3851

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