FXR Agonism with Bile Acid Mimetic Reduces Pre-Clinical Triple-Negative Breast Cancer Burden

FXR Agonism with Bile Acid Mimetic Reduces Pre-Clinical Triple-Negative Breast Cancer Burden

Bariatric surgery is associated with improved outcomes for several cancers, including breast cancer (BC), although the mechanisms mediating this protection are unknown. We hypothesized that elevated bile acid pools detected after bariatric surgery may be factors that contribute to improved BC outcom...

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Bibliographic Details
Main Authors: Sydney C. Joseph, Samson Eugin Simon, Margaret S. Bohm, Minjeong Kim, Madeline E. Pye, Boston W. Simmons, Dillon G. Graves, Stacey M. Thomas-Gooch, Ubaid A. Tanveer, Jeremiah R. Holt, Suriyan Ponnusamy, Laura M. Sipe, D. Neil Hayes, Katherine L. Cook, Ramesh Narayanan, Joseph F. Pierre, Liza Makowski
Format: Article
Language:English
Published: MDPI AG 2024-03-01
Series:Cancers
Subjects:
nuclear hormone receptor
agonist
bile acid receptor
FXR
TGR5
triple-negative breast cancer
Online Access:https://www.mdpi.com/2072-6694/16/7/1368

Internet

https://www.mdpi.com/2072-6694/16/7/1368

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