Synthesis and pharmacological activity of the epimers of hexahydrocannabinol (HHC)

Abstract Cannabis is a multifaceted plant with numerous therapeutic properties on one hand, and controversial psychotropic activities on the other hand, which are modulated by CB1 endocannabinoid receptors. Δ9-Tetrahydrocannabinol (Δ9-THC) has been identified as the main component responsible for th...

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Main Authors: Fabiana Russo, Maria Angela Vandelli, Giuseppe Biagini, Martin Schmid, Livio Luongo, Michela Perrone, Federica Ricciardi, Sabatino Maione, Aldo Laganà, Anna Laura Capriotti, Alfonso Gallo, Luigi Carbone, Elisabetta Perrone, Giuseppe Gigli, Giuseppe Cannazza, Cinzia Citti
Format: Article
Language:English
Published: Nature Portfolio 2023-07-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-023-38188-5