Permeant fluorescent probes visualize the activation of SARM1 and uncover an anti-neurodegenerative drug candidate

Permeant fluorescent probes visualize the activation of SARM1 and uncover an anti-neurodegenerative drug candidate

SARM1 regulates axonal degeneration through its NAD-metabolizing activity and is a drug target for neurodegenerative disorders. We designed and synthesized fluorescent conjugates of styryl derivative with pyridine to serve as substrates of SARM1, which exhibited large red shifts after conversion. Wi...

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Bibliographic Details
Main Authors: Wan Hua Li, Ke Huang, Yang Cai, Qian Wen Wang, Wen Jie Zhu, Yun Nan Hou, Sujing Wang, Sheng Cao, Zhi Ying Zhao, Xu Jie Xie, Yang Du, Chi-Sing Lee, Hon Cheung Lee, Hongmin Zhang, Yong Juan Zhao
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2021-05-01
Series:eLife
Subjects:
SARM1
fluorescent probes
base-exchange
allosteric inhibitors
CryoEM structure
covalent inhibitors
Online Access:https://elifesciences.org/articles/67381

Internet

https://elifesciences.org/articles/67381

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