Structural Consequence of Non-Synonymous Single-Nucleotide Variants in the N-Terminal Domain of LIS1

Structural Consequence of Non-Synonymous Single-Nucleotide Variants in the N-Terminal Domain of LIS1

Disruptive neuronal migration during early brain development causes severe brain malformation. Characterized by mislocalization of cortical neurons, this condition is a result of the loss of function of migration regulating genes. One known neuronal migration disorder is lissencephaly (LIS), which i...

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Bibliographic Details
Main Authors: Ho Jin Choi, Sarmistha Mitra, Yeasmin Akter Munni, Raju Dash, Sarmin Ummey Habiba, Md Sohel, Sultana Israt Jahan, Tae Jung Jang, Il Soo Moon
Format: Article
Language:English
Published: MDPI AG 2022-03-01
Series:International Journal of Molecular Sciences
Subjects:
<i>LIS1</i>
single nucleotide polymorphisms
molecular dynamics simulation
variant
lissencephaly
Online Access:https://www.mdpi.com/1422-0067/23/6/3109

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https://www.mdpi.com/1422-0067/23/6/3109

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