Mapk7 deletion in chondrocytes causes vertebral defects by reducing MEF2C/PTEN/AKT signaling

Mapk7 deletion in chondrocytes causes vertebral defects by reducing MEF2C/PTEN/AKT signaling

Mutation of the MAPK7 gene was related to human scoliosis. Mapk7 regulated the development of limb bones and skulls in mice. However, the role of MAPK7 in vertebral development is still unclear. In this study, we constructed Col2a1-cre; Mapk7f/f transgenic mouse model to delete Mapk7 in cartilage, w...

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Bibliographic Details
Main Authors: Chengzhi Wu, Hengyu Liu, Dongmei Zhong, Xiaoming Yang, Zhiheng Liao, Yuyu Chen, Shun Zhang, Deying Su, Baolin Zhang, Chuan Li, Liru Tian, Caixia Xu, Peiqiang Su
Format: Article
Language:English
Published: KeAi Communications Co., Ltd. 2024-03-01
Series:Genes and Diseases
Subjects:
Chondrocyte hypertrophy
Growth plate
Kyphosis
MAPK7
MEF2C
Osteopenia
Online Access:http://www.sciencedirect.com/science/article/pii/S2352304223000624

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http://www.sciencedirect.com/science/article/pii/S2352304223000624

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