NAMPT-Mediated NAD+ Biosynthesis Is Essential for Vision In Mice

NAMPT-Mediated NAD+ Biosynthesis Is Essential for Vision In Mice

Photoreceptor death is the endpoint of many blinding diseases. Identifying unifying pathogenic mechanisms in these diseases may offer global approaches for facilitating photoreceptor survival. We found that rod or cone photoreceptor-specific deletion of nicotinamide phosphoribosyltransferase (Nampt)...

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Bibliographic Details
Main Authors: Jonathan B. Lin, Shunsuke Kubota, Norimitsu Ban, Mitsukuni Yoshida, Andrea Santeford, Abdoulaye Sene, Rei Nakamura, Nicole Zapata, Miyuki Kubota, Kazuo Tsubota, Jun Yoshino, Shin-ichiro Imai, Rajendra S. Apte
Format: Article
Language:English
Published: Elsevier 2016-09-01
Series:Cell Reports
Subjects:
retina
neurodegeneration
photoreceptor
metabolism
NAD+
sirtuins
mitochondria
Online Access:http://www.sciencedirect.com/science/article/pii/S221112471631169X

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http://www.sciencedirect.com/science/article/pii/S221112471631169X

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