Modular metabolite assembly in Caenorhabditis elegans depends on carboxylesterases and formation of lysosome-related organelles

Modular metabolite assembly in Caenorhabditis elegans depends on carboxylesterases and formation of lysosome-related organelles

Signaling molecules derived from attachment of diverse metabolic building blocks to ascarosides play a central role in the life history of C. elegans and other nematodes; however, many aspects of their biogenesis remain unclear. Using comparative metabolomics, we show that a pathway mediating format...

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Bibliographic Details
Main Authors: Henry H Le, Chester JJ Wrobel, Sarah M Cohen, Jingfang Yu, Heenam Park, Maximilian J Helf, Brian J Curtis, Joseph C Kruempel, Pedro Reis Rodrigues, Patrick J Hu, Paul W Sternberg, Frank C Schroeder
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2020-10-01
Series:eLife
Subjects:
metabolomics
small molecule signaling
biosynthesis
natural products
ascarosides
modular metabolites
Online Access:https://elifesciences.org/articles/61886

Internet

https://elifesciences.org/articles/61886

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