Disruption of DDX53 coding sequence has limited impact on iPSC-derived human NGN2 neurons

Disruption of DDX53 coding sequence has limited impact on iPSC-derived human NGN2 neurons

Abstract Background The X-linked PTCHD1 locus is strongly associated with autism spectrum disorder (ASD). Males who carry chromosome microdeletions of PTCHD1 antisense long non-coding RNA (PTCHD1-AS)/DEAD-box helicase 53 (DDX53) have ASD, or a sub-clinical form called Broader Autism Phenotype. If th...

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Bibliographic Details
Main Authors: Muhammad Faheem, Eric Deneault, Roumiana Alexandrova, Deivid C. Rodrigues, Giovanna Pellecchia, Carole Shum, Mehdi Zarrei, Alina Piekna, Wei Wei, Jennifer L. Howe, Bhooma Thiruvahindrapuram, Sylvia Lamoureux, P. Joel Ross, Clarrisa A. Bradley, James Ellis, Stephen W. Scherer
Format: Article
Language:English
Published: BMC 2023-01-01
Series:BMC Medical Genomics
Subjects:
ASD
iPSCs
DDX53
PTCHD1-AS
CRISPR
NGN2
Online Access:https://doi.org/10.1186/s12920-022-01425-3

Internet

https://doi.org/10.1186/s12920-022-01425-3

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