Timely Leukapheresis May Interfere with the “Fitness” of Lymphocytes Collected for CAR-T Treatment in High Risk DLBCL Patients

Timely Leukapheresis May Interfere with the “Fitness” of Lymphocytes Collected for CAR-T Treatment in High Risk DLBCL Patients

The development of chimeric antigen receptor (CAR)-T cell therapy has revolutionized the treatment of hematological diseases. However, approximately 60% of patients relapse after CAR-T cell therapy, and no clear cause for this failure has been identified. The objective of the Bio-CAR-T BS study (Cli...

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Bibliographic Details
Main Authors: Mirko Farina, Marco Chiarini, Camillo Almici, Eugenia Accorsi Buttini, Francesco Zuccalà, Simone Piva, Irene Volonghi, Loris Poli, Simona Bernardi, Federica Colnaghi, Federica Re, Alessandro Leoni, Nicola Polverelli, Alessandro Turra, Enrico Morello, Anna Galvagni, Daniele Moratto, Duilio Brugnoni, Chiara Cattaneo, Emilio Ferrari, Andrea Bianchetti, Michele Malagola, Alessandro Re, Domenico Russo
Format: Article
Language:English
Published: MDPI AG 2022-10-01
Series:Cancers
Subjects:
CAR-T
Lymphocytes fitness
pre-emptive lymphocytoapheresis
T-cells repertoire
Online Access:https://www.mdpi.com/2072-6694/14/21/5276

Internet

https://www.mdpi.com/2072-6694/14/21/5276

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