Variable Induction of Pro-Inflammatory Cytokines by Commercial SARS CoV-2 Spike Protein Reagents: Potential Impacts of LPS on In Vitro Modeling and Pathogenic Mechanisms In Vivo

Variable Induction of Pro-Inflammatory Cytokines by Commercial SARS CoV-2 Spike Protein Reagents: Potential Impacts of LPS on In Vitro Modeling and Pathogenic Mechanisms In Vivo

Proinflammatory cytokine production following infection with severe acute respiratory syndrome coronavirus 2 (SARS CoV-2) is associated with poor clinical outcomes. Like SARS CoV-1, SARS CoV-2 enters host cells via its spike protein, which attaches to angiotensin-converting enzyme 2 (ACE2). As SARS...

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Bibliographic Details
Main Authors: Weiming Ouyang, Tao Xie, Hui Fang, Chunling Gao, Tzanko Stantchev, Kathleen A. Clouse, Kun Yuan, Tongzhong Ju, David M. Frucht
Format: Article
Language:English
Published: MDPI AG 2021-07-01
Series:International Journal of Molecular Sciences
Subjects:
SARS CoV-2
COVID-19
spike protein
ACE2
proinflammatory cytokine
endotoxin
Online Access:https://www.mdpi.com/1422-0067/22/14/7540

Internet

https://www.mdpi.com/1422-0067/22/14/7540

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