HIF-1α Regulates Osteogenesis of Periosteum-Derived Stem Cells Under Hypoxia Conditions via Modulating POSTN Expression

HIF-1α Regulates Osteogenesis of Periosteum-Derived Stem Cells Under Hypoxia Conditions via Modulating POSTN Expression

Periosteum is indispensable in bone repair and is an important source of skeletal stem cells (SSCs) for endogenous bone regeneration. However, there are only a few studies about SSCs in periosteum. The craniomaxillofacial bone regeneration is done under the hypoxia microenvironment, in which HIF-1α...

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Bibliographic Details
Main Authors: Yu Zhuang, Zhiyang Zhao, Mengjia Cheng, Meng Li, Jiawen Si, Kaili Lin, Hongbo Yu
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-02-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
periosteum-derived stem cells
hypoxia
HIF-1α
POSTN
bone regeneration
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2022.836285/full

Internet

https://www.frontiersin.org/articles/10.3389/fcell.2022.836285/full

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