Altered Frequency and Phenotype of HLA-G-Expressing DC-10 in Type 1 Diabetes Patients at Onset and in Subjects at Risk to Develop the Disease

Altered Frequency and Phenotype of HLA-G-Expressing DC-10 in Type 1 Diabetes Patients at Onset and in Subjects at Risk to Develop the Disease

Type 1 diabetes (T1D) is a chronic autoimmune disease resulting in progressive destruction of β-cells. Several factors affecting lymphocyte and antigen-presenting cells, including dendritic cells (DCs), contribute to defective maintenance of tolerance in T1D. DC-10 are a subset of human DCs involved...

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Bibliographic Details
Main Authors: Giada Amodio, Alessandra Mandelli, Rosalia Curto, Paola M. V. Rancoita, Angela Stabilini, Riccardo Bonfanti, Maurizio de Pellegrin, Emanuele Bosi, Clelia Di Serio, Manuela Battaglia, Silvia Gregori
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-10-01
Series:Frontiers in Immunology
Subjects:
DC-10
type 1 diabetes (T1D)
HLA-G
tolerogenic dendritic cells
pro-inflammatory myeloid cells
first-degree relatives (FDRs)
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.750162/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2021.750162/full

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