Sodium pyruvate exerts protective effects against cigarette smoke extract-induced ferroptosis in alveolar and bronchial epithelial cells through the GPX4/Nrf2 axis

Sodium pyruvate exerts protective effects against cigarette smoke extract-induced ferroptosis in alveolar and bronchial epithelial cells through the GPX4/Nrf2 axis

Abstract Background Ferroptosis in alveolar and bronchial epithelial cells is one of the main mechanisms underlying the development of chronic obstructive pulmonary disease (COPD). Sodium pyruvate (NaPyr) is a natural antioxidant in the body, exhibiting anti-inflammatory and antioxidant activities....

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Bibliographic Details
Main Authors: Ziwen Zhao, Zhao Xu, Jingwen Chang, Liwei He, Zijin Zhang, Xiaoyu Song, Xianbang Hou, Fangtian Fan, Zhijun Jiang
Format: Article
Language:English
Published: BMC 2023-08-01
Series:Journal of Inflammation
Subjects:
COPD
Sodium pyruvate
Ferroptosis
GPX4
Nrf2
Online Access:https://doi.org/10.1186/s12950-023-00347-w

Internet

https://doi.org/10.1186/s12950-023-00347-w

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