Differential Effects of Beta-Hydroxybutyrate Enantiomers on Induced Pluripotent Stem Derived Cardiac Myocyte Electrophysiology

Differential Effects of Beta-Hydroxybutyrate Enantiomers on Induced Pluripotent Stem Derived Cardiac Myocyte Electrophysiology

Beta-hydroxybutyrate (βOHB), along with acetoacetate and acetone, are liver-produced ketone bodies that are increased after fasting or prolonged exercise as an alternative fuel source to glucose. βOHB, as the main circulating ketone body, is not only a G-protein coupled receptor ligand but also a hi...

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Bibliographic Details
Main Authors: Matthew L. Klos, Wanqing Hou, Bernard Nsengimana, Shiwang Weng, Chuyun Yan, Suowen Xu, Eric Devaney, Shuxin Han
Format: Article
Language:English
Published: MDPI AG 2022-10-01
Series:Biomolecules
Subjects:
beta-hydroxybutyrate (βOHB)
induced pluripotent stem cell-derived cardiac myocytes (iPS-CMs)
enantiomer
racemic mixture
electrophysiology
Online Access:https://www.mdpi.com/2218-273X/12/10/1500

Internet

https://www.mdpi.com/2218-273X/12/10/1500

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