TNFRSF1B Gene Variants and Related Soluble TNFR2 Levels Impact Resilience in Alzheimer's Disease

TNFRSF1B Gene Variants and Related Soluble TNFR2 Levels Impact Resilience in Alzheimer's Disease

Tumor necrosis factor receptor 2 (TNFR2) promotes neuronal survival downstream. This longitudinal study evaluated whether the TNFRSF1B gene encoding TNFR2 and levels of its soluble form (sTNFR2) affect Alzheimer disease (AD) biomarkers and clinical outcomes. Data analyzed included 188 patients in th...

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Bibliographic Details
Main Authors: Jagan A. Pillai, Gurkan Bebek, Maria Khrestian, James Bena, Cornelia C. Bergmann, William S. Bush, James B. Leverenz, Lynn M. Bekris
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-02-01
Series:Frontiers in Aging Neuroscience
Subjects:
Alzheimer disease
neuroinflammation
TNFRSF1B
resilience
executive function
MCI
Online Access:https://www.frontiersin.org/articles/10.3389/fnagi.2021.638922/full

Internet

https://www.frontiersin.org/articles/10.3389/fnagi.2021.638922/full

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