Recombinant Human Plasma Gelsolin Stimulates Phagocytosis while Diminishing Excessive Inflammatory Responses in Mice with <i>Pseudomonas aeruginosa</i> Sepsis

Recombinant Human Plasma Gelsolin Stimulates Phagocytosis while Diminishing Excessive Inflammatory Responses in Mice with <i>Pseudomonas aeruginosa</i> Sepsis

Plasma gelsolin (pGSN) is a highly conserved abundant circulating protein, characterized by diverse immunomodulatory activities including macrophage activation and the ability to neutralize pro-inflammatory molecules produced by the host and pathogen. Using a murine model of Gram-negative sepsis ini...

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Bibliographic Details
Main Authors: Ewelina Piktel, Urszula Wnorowska, Mateusz Cieśluk, Piotr Deptuła, Suhanya V. Prasad, Grzegorz Król, Bonita Durnaś, Andrzej Namiot, Karolina H. Markiewicz, Katarzyna Niemirowicz-Laskowska, Agnieszka Z. Wilczewska, Paul A. Janmey, Joanna Reszeć, Robert Bucki
Format: Article
Language:English
Published: MDPI AG 2020-04-01
Series:International Journal of Molecular Sciences
Subjects:
plasma gelsolin
inflammation
phagocytosis
sepsis
<i>Pseudomonas aeruginosa</i>
Online Access:https://www.mdpi.com/1422-0067/21/7/2551

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https://www.mdpi.com/1422-0067/21/7/2551

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