Maximizing the potential of high-throughput next-generation sequencing through precise normalization based on read count distribution

Maximizing the potential of high-throughput next-generation sequencing through precise normalization based on read count distribution

ABSTRACT Next-generation sequencing technologies have enabled many advances across diverse areas of biology, with many benefiting from increased sample size. Although the cost of running next-generation sequencing instruments has dropped substantially over time, the cost of sample preparation method...

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Bibliographic Details
Main Authors: Caitriona Brennan, Rodolfo A. Salido, Pedro Belda-Ferre, MacKenzie Bryant, Charles Cowart, Maria D. Tiu, Antonio González, Daniel McDonald, Caitlin Tribelhorn, Amir Zarrinpar, Rob Knight
Format: Article
Language:English
Published: American Society for Microbiology 2023-08-01
Series:mSystems
Subjects:
metagenomics
large-scale studies
NGS normalization
automation
multiplexing
quantification
Online Access:https://journals.asm.org/doi/10.1128/msystems.00006-23

Internet

https://journals.asm.org/doi/10.1128/msystems.00006-23

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