In Vivo Anticoagulant and Antithrombic Activity of Depolymerized Glycosaminoglycan from <i>Apostichopus japonicus</i> and Dynamic Effect–Exposure Relationship in Rat Plasma

In Vivo Anticoagulant and Antithrombic Activity of Depolymerized Glycosaminoglycan from <i>Apostichopus japonicus</i> and Dynamic Effect–Exposure Relationship in Rat Plasma

Glycosaminoglycan from <i>Apostichopus japonicus</i> (AHG) and its depolymerized fragments (DAHGs) are anticoagulant fucosylated chondroitin sulfate. The aim of this study was to further evaluate the anticoagulant and antithrombic activity of AHG and DAHGs, as well as reveal the dynamic...

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Bibliographic Details
Main Authors: Han Wang, Dandan He, Linlin Duan, Lv Lv, Qun Gao, Yuanhong Wang, Shuang Yang, Zhihua Lv
Format: Article
Language:English
Published: MDPI AG 2022-10-01
Series:Marine Drugs
Subjects:
<i>Apostichopus japonicus</i>
glycosaminoglycan
antithrombotic
oral anticoagulant
effect–exposure relationship
Online Access:https://www.mdpi.com/1660-3397/20/10/631

Internet

https://www.mdpi.com/1660-3397/20/10/631

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