Transcription Factor EB Activation Rescues Advanced αB‐Crystallin Mutation‐Induced Cardiomyopathy by Normalizing Desmin Localization

Transcription Factor EB Activation Rescues Advanced αB‐Crystallin Mutation‐Induced Cardiomyopathy by Normalizing Desmin Localization

Background Mutations in αB‐crystallin result in proteotoxic cardiomyopathy with desmin mislocalization to protein aggregates. Intermittent fasting (IF) is a novel approach to activate transcription factor EB (TFEB), a master regulator of the autophagy‐lysosomal pathway, in the myocardium. We tested...

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Bibliographic Details
Main Authors: Xiucui Ma, Kartik Mani, Haiyan Liu, Attila Kovacs, John T. Murphy, Layla Foroughi, Brent A. French, Carla J. Weinheimer, Aldi Kraja, Ivor J. Benjamin, Joseph A. Hill, Ali Javaheri, Abhinav Diwan
Format: Article
Language:English
Published: Wiley 2019-02-01
Series:Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Subjects:
cardiomyopathy
HspB8
intermittent fasting
protein aggregates
TFEB
αB‐crystallin
Online Access:https://www.ahajournals.org/doi/10.1161/JAHA.118.010866

Internet

https://www.ahajournals.org/doi/10.1161/JAHA.118.010866

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