In Vivo Bioavailability of Selenium in Selenium-Enriched <i>Streptococcus thermophilus</i> and <i>Enterococcus faecium</i> in CD IGS Rats
The selenium (Se) enrichment of yeasts and lactic acid bacteria (LAB) has recently emerged as a novel concept; the individual health effects of these beneficial microorganisms are combined by supplying the essential micronutrient Se in a more bioavailable and less toxic form. This study investigated...
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MDPI AG
2021-03-01
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| Series: | Antioxidants |
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| Online Access: | https://www.mdpi.com/2076-3921/10/3/463 |
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| author | Gabriela Krausova Antonin Kana Marek Vecka Ivana Hyrslova Barbora Stankova Vera Kantorova Iva Mrvikova Martina Huttl Hana Malinska |
| author_facet | Gabriela Krausova Antonin Kana Marek Vecka Ivana Hyrslova Barbora Stankova Vera Kantorova Iva Mrvikova Martina Huttl Hana Malinska |
| author_sort | Gabriela Krausova |
| collection | DOAJ |
| description | The selenium (Se) enrichment of yeasts and lactic acid bacteria (LAB) has recently emerged as a novel concept; the individual health effects of these beneficial microorganisms are combined by supplying the essential micronutrient Se in a more bioavailable and less toxic form. This study investigated the bioavailability of Se in the strains <i>Enterococcus faecium</i> CCDM 922A (EF) and <i>Streptococcus thermophilus</i> CCDM 144 (ST) and their respective Se-enriched forms, SeEF and SeST, in a CD (SD-Sprague Dawley) IGS rat model. Se-enriched LAB administration resulted in higher Se concentrations in the liver and kidneys of rats, where selenocystine was the prevalent Se species. The administration of both Se-enriched strains improved the antioxidant status of the animals. The effect of the diet was more pronounced in the heart tissue, where a lower glutathione reductase content was observed, irrespective of the Se fortification in LAB. Interestingly, rats fed diets with EF and SeEF had higher glutathione reductase activity. Reduced concentrations of serum malondialdehyde were noted following Se supplementation. Diets containing Se-enriched strains showed no macroscopic effects on the liver, kidneys, heart, and brain and had no apparent influence on the basic parameters of the lipid metabolism. Both the strains tested herein showed potential for further applications as promising sources of organically bound Se and Se nanoparticles. |
| first_indexed | 2024-03-10T13:12:49Z |
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| institution | Directory Open Access Journal |
| issn | 2076-3921 |
| language | English |
| last_indexed | 2024-03-10T13:12:49Z |
| publishDate | 2021-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antioxidants |
| spelling | doaj.art-ad80607e77694d86a5d725b1afa94bb62023-11-21T10:40:07ZengMDPI AGAntioxidants2076-39212021-03-0110346310.3390/antiox10030463In Vivo Bioavailability of Selenium in Selenium-Enriched <i>Streptococcus thermophilus</i> and <i>Enterococcus faecium</i> in CD IGS RatsGabriela Krausova0Antonin Kana1Marek Vecka2Ivana Hyrslova3Barbora Stankova4Vera Kantorova5Iva Mrvikova6Martina Huttl7Hana Malinska8Department of Microbiology and Technology, Dairy Research Institute, Ltd., Ke Dvoru 12a, 160 00 Prague, Czech RepublicDepartment of Analytical Chemistry, Faculty of Chemical Engineering, University of Chemistry and Technology Prague, Technicka 5, 166 28 Prague, Czech Republic4th Department of Medicine Department of Gastroenterology and Hepatology, First Faculty of Medicine, Charles University in Prague, U Nemocnice 2, 128 00 Prague, Czech RepublicDepartment of Microbiology and Technology, Dairy Research Institute, Ltd., Ke Dvoru 12a, 160 00 Prague, Czech Republic4th Department of Medicine Department of Gastroenterology and Hepatology, First Faculty of Medicine, Charles University in Prague, U Nemocnice 2, 128 00 Prague, Czech RepublicDepartment of Analytical Chemistry, Faculty of Chemical Engineering, University of Chemistry and Technology Prague, Technicka 5, 166 28 Prague, Czech RepublicDepartment of Microbiology and Technology, Dairy Research Institute, Ltd., Ke Dvoru 12a, 160 00 Prague, Czech RepublicCentre for Experimental Medicine, Institute for Clinical and Experimental Medicine (IKEM), Videnska 1958/9, 140 21 Prague, Czech RepublicCentre for Experimental Medicine, Institute for Clinical and Experimental Medicine (IKEM), Videnska 1958/9, 140 21 Prague, Czech RepublicThe selenium (Se) enrichment of yeasts and lactic acid bacteria (LAB) has recently emerged as a novel concept; the individual health effects of these beneficial microorganisms are combined by supplying the essential micronutrient Se in a more bioavailable and less toxic form. This study investigated the bioavailability of Se in the strains <i>Enterococcus faecium</i> CCDM 922A (EF) and <i>Streptococcus thermophilus</i> CCDM 144 (ST) and their respective Se-enriched forms, SeEF and SeST, in a CD (SD-Sprague Dawley) IGS rat model. Se-enriched LAB administration resulted in higher Se concentrations in the liver and kidneys of rats, where selenocystine was the prevalent Se species. The administration of both Se-enriched strains improved the antioxidant status of the animals. The effect of the diet was more pronounced in the heart tissue, where a lower glutathione reductase content was observed, irrespective of the Se fortification in LAB. Interestingly, rats fed diets with EF and SeEF had higher glutathione reductase activity. Reduced concentrations of serum malondialdehyde were noted following Se supplementation. Diets containing Se-enriched strains showed no macroscopic effects on the liver, kidneys, heart, and brain and had no apparent influence on the basic parameters of the lipid metabolism. Both the strains tested herein showed potential for further applications as promising sources of organically bound Se and Se nanoparticles.https://www.mdpi.com/2076-3921/10/3/463selenium-enriched <i>Enterococcus faecium</i>selenium-enriched <i>Streptococcus thermophilus</i>antioxidant capacityglutathione reductaseglutathione peroxidaseCD IGS rats |
| spellingShingle | Gabriela Krausova Antonin Kana Marek Vecka Ivana Hyrslova Barbora Stankova Vera Kantorova Iva Mrvikova Martina Huttl Hana Malinska In Vivo Bioavailability of Selenium in Selenium-Enriched <i>Streptococcus thermophilus</i> and <i>Enterococcus faecium</i> in CD IGS Rats Antioxidants selenium-enriched <i>Enterococcus faecium</i> selenium-enriched <i>Streptococcus thermophilus</i> antioxidant capacity glutathione reductase glutathione peroxidase CD IGS rats |
| title | In Vivo Bioavailability of Selenium in Selenium-Enriched <i>Streptococcus thermophilus</i> and <i>Enterococcus faecium</i> in CD IGS Rats |
| title_full | In Vivo Bioavailability of Selenium in Selenium-Enriched <i>Streptococcus thermophilus</i> and <i>Enterococcus faecium</i> in CD IGS Rats |
| title_fullStr | In Vivo Bioavailability of Selenium in Selenium-Enriched <i>Streptococcus thermophilus</i> and <i>Enterococcus faecium</i> in CD IGS Rats |
| title_full_unstemmed | In Vivo Bioavailability of Selenium in Selenium-Enriched <i>Streptococcus thermophilus</i> and <i>Enterococcus faecium</i> in CD IGS Rats |
| title_short | In Vivo Bioavailability of Selenium in Selenium-Enriched <i>Streptococcus thermophilus</i> and <i>Enterococcus faecium</i> in CD IGS Rats |
| title_sort | in vivo bioavailability of selenium in selenium enriched i streptococcus thermophilus i and i enterococcus faecium i in cd igs rats |
| topic | selenium-enriched <i>Enterococcus faecium</i> selenium-enriched <i>Streptococcus thermophilus</i> antioxidant capacity glutathione reductase glutathione peroxidase CD IGS rats |
| url | https://www.mdpi.com/2076-3921/10/3/463 |
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