A Deficiency of the Psychiatric Risk Gene DLG2/PSD-93 Causes Excitatory Synaptic Deficits in the Dorsolateral Striatum

A Deficiency of the Psychiatric Risk Gene DLG2/PSD-93 Causes Excitatory Synaptic Deficits in the Dorsolateral Striatum

Genetic variations resulting in the loss of function of the discs large homologs (DLG2)/postsynaptic density protein-93 (PSD-93) gene have been implicated in the increased risk for schizophrenia, intellectual disability, and autism spectrum disorders (ASDs). Previously, we have reported that mice la...

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Bibliographic Details
Main Authors: Taesun Yoo, Shambhu Joshi, Sanjaya Prajapati, Yi Sul Cho, Jinkyeong Kim, Pil-Hoon Park, Yong Chul Bae, Eunjoon Kim, Soo Young Kim
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-07-01
Series:Frontiers in Molecular Neuroscience
Subjects:
MAGUK
dorsolateral striatum
spiny projection neurons
corticostriatal transmission
schizophrenia risk gene
Online Access:https://www.frontiersin.org/articles/10.3389/fnmol.2022.938590/full

Internet

https://www.frontiersin.org/articles/10.3389/fnmol.2022.938590/full

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