Regulatory T Cells Increase After rh-MOG Stimulation in Non-Relapsing but Decrease in Relapsing MOG Antibody-Associated Disease at Onset in Children

Regulatory T Cells Increase After rh-MOG Stimulation in Non-Relapsing but Decrease in Relapsing MOG Antibody-Associated Disease at Onset in Children

BackgroundMyelin oligodendrocytes glycoprotein (MOG) antibody-associated disease (MOGAD) represent 25% of pediatric acquired demyelinating syndrome (ADS); 40% of them may relapse, mimicking multiple sclerosis (MS), a recurrent and neurodegenerative ADS, which is MOG-Abs negative.AimsTo identify MOG...

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Main Authors: Philippe Horellou, Aliénor de Chalus, Laetitia Giorgi, Carole Leroy, Pascale Chrétien, Salima Hacein-Bey-Abina, Christine Bourgeois, Xavier Mariette, Ché Serguera, Roger Le Grand, Kumaran Deiva
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-06-01
Series:Frontiers in Immunology
Subjects:
neuroinflammation
auto-immune diseases
acquired demyelinating syndromes (ADS)
myelin oligodendrocyte glycoprotein
multiple sclerosis
regulatory T lymphocytes
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.679770/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2021.679770/full

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