Virus-like particle vaccine displaying an external, membrane adjacent MUC16 epitope elicits ovarian cancer-reactive antibodies

Virus-like particle vaccine displaying an external, membrane adjacent MUC16 epitope elicits ovarian cancer-reactive antibodies

Abstract Background MUC16 is a heavily glycosylated cell surface mucin cleaved in the tumor microenvironment to shed CA125. CA125 is a serum biomarker expressed by > 95% of non-mucinous advanced stage epithelial ovarian cancers. MUC16/CA125 contributes to the evasion of anti-tumor immunity, perit...

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Bibliographic Details
Main Authors: Hsin-Fang Tu, Margaret Wong, Ssu-Hsueh Tseng, Nattha Ingavat, Pola Olczak, Kin Israel Notarte, Chien-fu Hung, Richard B.S. Roden
Format: Article
Language:English
Published: BMC 2024-01-01
Series:Journal of Ovarian Research
Subjects:
MUC16
CA125
Antibody
Virus-like particle
Vaccination
Ovarian cancer
Online Access:https://doi.org/10.1186/s13048-023-01325-9

Internet

https://doi.org/10.1186/s13048-023-01325-9

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