Heparin Mimics Extracellular DNA in Binding to Cell Surface-Localized Proteins and Promoting <named-content content-type="genus-species">Staphylococcus aureus</named-content> Biofilm Formation

Heparin Mimics Extracellular DNA in Binding to Cell Surface-Localized Proteins and Promoting <named-content content-type="genus-species">Staphylococcus aureus</named-content> Biofilm Formation

ABSTRACT Staphylococcus aureus is a leading cause of catheter-related bloodstream infections. Biofilms form on these implants and are held together by a matrix composed of proteins, polysaccharides, and extracellular DNA (eDNA). Heparin is a sulfated glycosaminoglycan that is routinely used in centr...

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Bibliographic Details
Main Authors: Surabhi Mishra, Alexander R. Horswill
Format: Article
Language:English
Published: American Society for Microbiology 2017-06-01
Series:mSphere
Subjects:
heparin
Staphylococcus aureus
biofilm
eDNA
glycosaminoglycan
MRSA
Online Access:https://journals.asm.org/doi/10.1128/mSphere.00135-17

Internet

https://journals.asm.org/doi/10.1128/mSphere.00135-17

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