Oxidative insult can induce malaria-protective trait of sickle and fetal erythrocytes
Carriers of haemoglobinopathies are protected from severe malaria, likely due to reduced surface expression of virulence factors. Here, Cyrklaff et al. show that, similar to haemoglobinopathies, a transient oxidative insult affects actin reorganization and mitigates the development of cerebral malar...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2016-11-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/ncomms13401 |
| _version_ | 1828976622978465792 |
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| author | Marek Cyrklaff Sirikamol Srismith Britta Nyboer Kvetoslava Burda Angelika Hoffmann Felix Lasitschka Sophie Adjalley Cyrille Bisseye Jacques Simpore Ann-Kristin Mueller Cecilia P. Sanchez Friedrich Frischknecht Michael Lanzer |
| author_facet | Marek Cyrklaff Sirikamol Srismith Britta Nyboer Kvetoslava Burda Angelika Hoffmann Felix Lasitschka Sophie Adjalley Cyrille Bisseye Jacques Simpore Ann-Kristin Mueller Cecilia P. Sanchez Friedrich Frischknecht Michael Lanzer |
| author_sort | Marek Cyrklaff |
| collection | DOAJ |
| description | Carriers of haemoglobinopathies are protected from severe malaria, likely due to reduced surface expression of virulence factors. Here, Cyrklaff et al. show that, similar to haemoglobinopathies, a transient oxidative insult affects actin reorganization and mitigates the development of cerebral malaria in mice. |
| first_indexed | 2024-12-14T14:40:48Z |
| format | Article |
| id | doaj.art-ad8f730d0ece4e689ceb8d952125110c |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-14T14:40:48Z |
| publishDate | 2016-11-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-ad8f730d0ece4e689ceb8d952125110c2022-12-21T22:57:25ZengNature PortfolioNature Communications2041-17232016-11-017111110.1038/ncomms13401Oxidative insult can induce malaria-protective trait of sickle and fetal erythrocytesMarek Cyrklaff0Sirikamol Srismith1Britta Nyboer2Kvetoslava Burda3Angelika Hoffmann4Felix Lasitschka5Sophie Adjalley6Cyrille Bisseye7Jacques Simpore8Ann-Kristin Mueller9Cecilia P. Sanchez10Friedrich Frischknecht11Michael Lanzer12Center of Infectious Diseases, Parasitology, Heidelberg University HospitalCenter of Infectious Diseases, Parasitology, Heidelberg University HospitalCenter of Infectious Diseases, Parasitology, Heidelberg University HospitalFaculty of Physics and Applied Computer Science, AGH—University of Science and Technology in KrakówDepartment of Neuroradiology, Heidelberg University HospitalGerman Centre for Infection Research (DZIF), Partner Site HeidelbergEuropean Molecular Biology Laboratory (EMBL)Biomolecular Research Center Pietro Annigoni, University of OuagadougouBiomolecular Research Center Pietro Annigoni, University of OuagadougouCenter of Infectious Diseases, Parasitology, Heidelberg University HospitalCenter of Infectious Diseases, Parasitology, Heidelberg University HospitalCenter of Infectious Diseases, Parasitology, Heidelberg University HospitalCenter of Infectious Diseases, Parasitology, Heidelberg University HospitalCarriers of haemoglobinopathies are protected from severe malaria, likely due to reduced surface expression of virulence factors. Here, Cyrklaff et al. show that, similar to haemoglobinopathies, a transient oxidative insult affects actin reorganization and mitigates the development of cerebral malaria in mice.https://doi.org/10.1038/ncomms13401 |
| spellingShingle | Marek Cyrklaff Sirikamol Srismith Britta Nyboer Kvetoslava Burda Angelika Hoffmann Felix Lasitschka Sophie Adjalley Cyrille Bisseye Jacques Simpore Ann-Kristin Mueller Cecilia P. Sanchez Friedrich Frischknecht Michael Lanzer Oxidative insult can induce malaria-protective trait of sickle and fetal erythrocytes Nature Communications |
| title | Oxidative insult can induce malaria-protective trait of sickle and fetal erythrocytes |
| title_full | Oxidative insult can induce malaria-protective trait of sickle and fetal erythrocytes |
| title_fullStr | Oxidative insult can induce malaria-protective trait of sickle and fetal erythrocytes |
| title_full_unstemmed | Oxidative insult can induce malaria-protective trait of sickle and fetal erythrocytes |
| title_short | Oxidative insult can induce malaria-protective trait of sickle and fetal erythrocytes |
| title_sort | oxidative insult can induce malaria protective trait of sickle and fetal erythrocytes |
| url | https://doi.org/10.1038/ncomms13401 |
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