Blockade of CD73 Increases the Cytotoxic Effects of Fludarabine in Chronic Lymphocytic Leukemia

Blockade of CD73 Increases the Cytotoxic Effects of Fludarabine in Chronic Lymphocytic Leukemia

Background: Ecto-5’-nucleotidase (CD73) is a membrane-bound enzyme that converts adenosine 5’-monophosphate into adenosine. It is proven that the presence of elevated levels of adenosine in the tumor microenvironment induces tumor growth while suppressing immune responses against tumor cells. Accord...

Full description

Bibliographic Details
Main Authors: Mohammad Sadeghi, Mahsa Yousefi Bostanabad, Omid Abedi, Abbas Ali Hosseinpour Feizi, Ali Akbar Movasaghpour Akbari, Farhad Jadidi-Niaragh
Format: Article
Language:English
Published: Tabriz University of Medical Sciences 2022-12-01
Series:ImmunoAnalysis
Subjects:
cll
fludarabine
cd73
leukemia
sirna
chemoresistance
Online Access:https://ia.tbzmed.ac.ir/PDF/ia-2-11.pdf

Internet

https://ia.tbzmed.ac.ir/PDF/ia-2-11.pdf

Similar Items