Integrating single-cell RNA-seq and spatial transcriptomics reveals MDK-NCL dependent immunosuppressive environment in endometrial carcinoma

Integrating single-cell RNA-seq and spatial transcriptomics reveals MDK-NCL dependent immunosuppressive environment in endometrial carcinoma

ObjectivesThe tumor microenvironment (TME) play important roles in progression of endometrial carcinoma (EC). We aimed to assess the cell populations in TME of EC.MethodsWe downloaded datasets of single-cell RNA-seq (scRNA-seq) and spatial transcriptome (ST) for EC from GEO, and downloaded RNA-Seq (...

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Bibliographic Details
Main Authors: Xinnian Yu, Linjun Xie, Jianjuan Ge, Huixin Li, Shanliang Zhong, Xiaolin Liu
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-04-01
Series:Frontiers in Immunology
Subjects:
endometrial cancer
scRNA-seq
spatial transcriptome
tumor microenvironment
midkine
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1145300/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2023.1145300/full

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