Anti-tumor effects of P-LPK-CPT, a peptide-camptothecin conjugate, in colorectal cancer

Anti-tumor effects of P-LPK-CPT, a peptide-camptothecin conjugate, in colorectal cancer

A peptide that specifically targets amino acid transporter SLC1A5 in colorectal cancer cells is identified and conjugated with camptothecin to show selective cytotoxicity to colorectal cancer cells in preclinical models.

Bibliographic Details
Main Authors: Lidan Hou, Yichao Hou, Yu Liang, Baiyu Chen, Xintian Zhang, Yu Wang, Kun Zhou, Ting Zhong, Bohan Long, Wenjing Pang, Lei Wang, Xu Han, Linjing Li, Ci Xu, Isabelle Gross, Christian Gaiddon, Wei Fu, Han Yao, Xiangjun Meng
Format: Article
Language:English
Published: Nature Portfolio 2022-11-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-022-04191-1

Internet

https://doi.org/10.1038/s42003-022-04191-1

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