Activation of p38MAPK contributes to expanded polyglutamine-induced cytotoxicity.
The signaling pathways that may modulate the pathogenesis of diseases induced by expanded polyglutamine proteins are not well understood.Herein we demonstrate that expanded polyglutamine protein cytotoxicity is mediated primarily through activation of p38MAPK and that the atypical PKC iota (PKCiota)...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2008-05-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC2330164?pdf=render |