Graphdiyne oxide nanosheets display selective anti-leukemia efficacy against DNMT3A-mutant AML cells

Graphdiyne oxide nanosheets display selective anti-leukemia efficacy against DNMT3A-mutant AML cells

DNA methyltransferase 3A, a mutated gene associated with hematologic malignancies in age-related clonal haematopoiesis lacks targeted therapies. Here, the authors screen carbon nanomaterials and find graphdiyne oxide binds to mutant cells and disrupts cellular processes with a therapeutic effect in...

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Bibliographic Details
Main Authors: Qiwei Wang, Ying Liu, Hui Wang, Penglei Jiang, Wenchang Qian, Min You, Yingli Han, Xin Zeng, Jinxin Li, Huan Lu, Lingli Jiang, Meng Zhu, Shilin Li, Kang Huang, Mingmin Tang, Xinlian Wang, Liang Yan, Zecheng Xiong, Xinghua Shi, Ge Bai, Huibiao Liu, Yuliang Li, Yuliang Zhao, Chunying Chen, Pengxu Qian
Format: Article
Language:English
Published: Nature Portfolio 2022-09-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-022-33410-w

Internet

https://doi.org/10.1038/s41467-022-33410-w

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