Sulfonated Amphiphilic Poly(α)glutamate Amine—A Potential siRNA Nanocarrier for the Treatment of Both Chemo-Sensitive and Chemo-Resistant Glioblastoma Tumors

Sulfonated Amphiphilic Poly(α)glutamate Amine—A Potential siRNA Nanocarrier for the Treatment of Both Chemo-Sensitive and Chemo-Resistant Glioblastoma Tumors

Development of chemo-resistance is a major challenge in glioblastoma (GB) treatment. This phenomenon is often driven by increased activation of genes associated with DNA repair, such as the alkyl-removing enzyme O<sup>6</sup>-methylguanine-DNA methyltransferase (MGMT) in combination with...

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Bibliographic Details
Main Authors: Adva Krivitsky, Sabina Pozzi, Eilam Yeini, Sahar Israeli Dangoor, Tal Zur, Sapir Golan, Vadim Krivitsky, Nitzan Albeck, Evgeny Pisarevsky, Paula Ofek, Asaf Madi, Ronit Satchi-Fainaro
Format: Article
Language:English
Published: MDPI AG 2021-12-01
Series:Pharmaceutics
Subjects:
nanocarrier
polyplexes
siRNA delivery
glioblastoma therapy
amphiphilic poly(α)glutamate
P-selectin
Online Access:https://www.mdpi.com/1999-4923/13/12/2199

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https://www.mdpi.com/1999-4923/13/12/2199

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