Alpha1-Adrenergic Receptor Activation Stimulates Calcium Entry and Proliferation via TRPC6 Channels in Cultured Human Mesangial Cells

Alpha1-Adrenergic Receptor Activation Stimulates Calcium Entry and Proliferation via TRPC6 Channels in Cultured Human Mesangial Cells

Background and Aims: There is accumulating evidence that sympathetic nervous hyperactivity contributes to the pathogenesis of glomerular sclerosis independent of blood pressure effects. A previous study showed that α1-adrenoceptor (α1-AR) antagonists inhibit mesangial cell (MC) proliferation. Howeve...

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Bibliographic Details
Main Authors: Fanwu Kong, Linlin Ma, Li Zou, Kexin Meng, Tianrong Ji, Lei Zhang, Rui Zhang, Jundong Jiao
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2015-07-01
Series:Cellular Physiology and Biochemistry
Subjects:
Adrenoceptor
ERK signaling
TRPC6
Mesangial cells
Online Access:http://www.karger.com/Article/FullText/430161

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http://www.karger.com/Article/FullText/430161

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