Tenascin-C drives persistence of organ fibrosis

Tenascin-C drives persistence of organ fibrosis

Systemic sclerosis (SSc) is a fibrotic disease affecting multiple organs. Here the authors use patient samples plus mouse studies to show a central role for tenascin C as a TLR4 activator responsible for persistence of fibrosis in the context of SSc and SSc-like disease.

Bibliographic Details
Main Authors: Swati Bhattacharyya, Wenxia Wang, Luisa Morales-Nebreda, Gang Feng, Minghua Wu, Xiaodong Zhou, Robert Lafyatis, Jungwha Lee, Monique Hinchcliff, Carol Feghali-Bostwick, Katja Lakota, G. R. Scott Budinger, Kirtee Raparia, Zenshiro Tamaki, John Varga
Format: Article
Language:English
Published: Nature Portfolio 2016-06-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/ncomms11703

Internet

https://doi.org/10.1038/ncomms11703

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