Wee1 Rather Than Plk1 Is Inhibited by AZD1775 at Therapeutically Relevant Concentrations

Wee1 Rather Than Plk1 Is Inhibited by AZD1775 at Therapeutically Relevant Concentrations

Wee1 kinase is an inhibitor of cyclin-dependent kinase (cdk)s, crucial cell cycle progression drivers. By phosphorylating cdk1 at tyrosine 15, Wee1 inhibits activation of cyclin B-cdk1 (Cdk1), preventing cells from entering mitosis with incompletely replicated or damaged DNA. Thus, inhibiting Wee1,...

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Bibliographic Details
Main Authors: Angela Flavia Serpico, Giuseppe D’Alterio, Cinzia Vetrei, Rosa Della Monica, Luca Nardella, Roberta Visconti, Domenico Grieco
Format: Article
Language:English
Published: MDPI AG 2019-06-01
Series:Cancers
Subjects:
Wee1 inhibitor
Plk1 inhibitor
DNA replication checkpoint
combination therapy
concentration range
Online Access:https://www.mdpi.com/2072-6694/11/6/819

Internet

https://www.mdpi.com/2072-6694/11/6/819

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