Direct cleavage of caspase-8 by herpes simplex virus 1 tegument protein US11

Abstract The HSV-1 tegument protein Us11 counteracts the antiviral defense mechanisms by precluding the host protein shutoff. Previous works demonstrated that Us11 prevents heat-and staurosporine-induced apoptosis and inhibits autophagy. Therefore, in the present study, we investigated the hypothesi...

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Bibliographic Details
Main Authors: Maria Musarra-Pizzo, Rosamaria Pennisi, Daniele Lombardo, Tania Velletri, Maria Teresa Sciortino
Format: Article
Language:English
Published: Nature Portfolio 2022-07-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-022-15942-9